E ISSN: 2583-049X

International Journal of Advanced Multidisciplinary Research and Studies

Volume 2, Issue 6, 2022

Qualitative Evaluation of Marketed Cardiovascular Drug Atorvastatin

Author(s): Rozina Parul, Ananta Kumar Das, Mahfuza Khatoon, Tania Ahmed, Binita Bilkis


Atorvastatin (INN) marketed as a calcium salt under the trade name Lipitor is a member of the drug class statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Ten different brands of selected company were evaluated for their in-vivo properties. For evaluated in-vivo properties are included assay, hardness, thickness, friability, weight variation, content uniformity, disintegration and dissolution. This assay was done with ten Pharmaceuticals and their brands are Drug International Ltd., OPSONIN Pharma Limited, SQUARE, General Pharma Ltd., Beximco Pharma Ltd., Pacific pharma Ltd., Aventis Pharmaceutical Ltd., SK+F, Orient, Unimed & Unihealth Ltd., and Divastin, Avas, Anzitor, Lipitin, Atova, Lipigent, Orva, Lipicon, Lipex, Stacor respectively. These ten brands were evaluated separately even no significant statistical variation observed. The assay analysis of ten brands of these company was tested and results within by thickness (4.7 – 3.0) mm, diameter (11.6 – 6.4) mm, hardness (3.17 - 0.90) kg, disintegration time (0.17 – 2.91) min, Dissolution time (25 – 5) min, UV method (99.0 – 83) % and HPLC method (98.7 – 95.2) %. From this comparative study of 10 mg Atorvastatin tablet of these ten pharmaceutical companies meet in vivo test parameters. All results are within in the range. So, we conclude that the quality of 10 mg Atorvastatin tablet of these ten pharmaceutical companies were well evaluated.

Keywords: Atorvastatin tablets, Thickness, Diameter

Pages: 495-499

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