Compare the Hypoglycemic Properties of Ultrasound Assisted Aqueous Extract of Argemone mexicana with methanol extract

Argemone mexicana is locally known as shial kata, is widely grown in abandoned fields all over Bangladesh. Ethnobotanical study witnessed that roots, latex, stems, leaves etc. all are medicinally rich and widely prescribed in different communities of Santal tribe for the different diseases along with diabetes. The present study was designed to scan the anti-diabetic properties of the whole plants of A. mexicana. The study was also emphasized on developing a green extraction method by introducing ultrasound assisted extraction in aqueous medium from fresh plants. The intended crude extracts were then compared to the conventional extraction methods such as aqueous decoction and the methanol cold extraction method. Hypoglycemic study was conducted by using glucocorticoid hormone dependent diabetes mice and the potency was compared to the standard antidiabetic drug glibenclamide. Results indicated that chronic administration of the crude extracts obtained from A. mexicana plants significantly reduced the fasting glucose level of the diabetic animal model. Even a slight weight gaining effect was also observed during the treatment by A. mexicana plant’s extract.