Effect of levofloxacin antibiotic on the body weight and some biochemical parameters in male rats

Levofloxacin (LFX) is one of the antibiotics that belongs to the family of fluoroquinolones and is used to treat several types of diseases caused by bacteria sensitive to these antibiotics, this drug belongs to the third generation of fluoroquinolones which have high activity against most gram- positive and gram-negative aerobic microorganisms. In the current study, we evaluated the possible effect of LFX on body weight of male rats. Rats (twenty) were randomly divided into 2 equal groups. Control group the rats were treated orally with distilled water, LFX group; the rats received LFX at a dose of 40ml kg-1 B.W orally day after day for 6 weeks by stomach tube. Intoxication of rats with LFX non significantly resulted in a decrease in the body weight in compared with the control group. Regarding to the liver function biomarkers of rats, LFX has no effect on serum total protein and albumin compared to the control group.